Short-term efficacy of peripheral nerve stimulation for essential tremor in a randomized double-blind controlled trial.

ABSTRACT: Peripheral nerve stimulation (PNS) demonstrates promise for some neurological conditions. However, its effectiveness for essential tremor (ET) requires further research. In this randomized, double-blind, sham-controlled trial, we investigated the safety and efficacy of a single, 40-minute PNS session in ET. Eighty-eight participants (age: 63.5 [52.5, 70.3], male: 57.95%) were assigned to active PNS stimulation (n = 45) or sham procedure (n = 43). Efficacy was assessed using accelerometer-measured tremor amplitude (m/s²), clinician-rated tremor severity using the Tremor Research Group Essential Tremor Rating Assessment Scale (TETRAS), patients' own experience with daily activities using the Bain and Findley Activities of Daily Living scale (BF-ADL), and their perceived improvement based on

SUBMITTER: Samiee R 

PROVIDER: S-EPMC12328561 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature