Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder.

ABSTRACT: In healthy individuals, active hand-movements typically elicit earlier neural processing than passive one, reflected by more positive contrast estimates of the first-order temporal derivative (TD) of hemodynamic response function (HRF) in functional MRI (fMRI) analyses. This temporal advantage might be due to prior movement-awareness and predictive mechanisms that support self-other distinction. However, it is unknown whether impaired predictive mechanisms in Schizophrenia Spectrum Disorder (SSD) influence earlier neural processing. Patients with SSD (n = 20) and healthy controls (HC; n = 20) performed active and passive hand movements, while detected delays in video feedback of their own or another person's hand. The recorded fMRI data were analysed applying TD to examine timing and secon

SUBMITTER: Rashid HA 

PROVIDER: S-EPMC12328563 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature