Epigenome-wide association study of BMI and waist-to-hip ratio and their associations with dietary patterns in Korean adults.

ABSTRACT: Obesity and abdominal obesity contribute to significant metabolic health risks through distinct pathophysiological mechanisms. We conducted an epigenome-wide association study to identify differential DNA methylation patterns associated with body mass index (BMI)-defined and abdominal obesity and explore their relationships with dietary intake among Korean adults (n = 1,526). We identified 23 and 1931 DMPs associated with abdominal obesity and severe BMI-defined obesity, respectively, with four CpG sites common to both phenotypes. The most significant associations were at cg10323433 and cg10501210 in serotonin receptor 2 A (HTR2A) for abdominal obesity (Δβ = -0.023) and BMI-defined obesity (Δβ = -0.021), respectively. Most DMPs (> 75%) exhibited hypomethylation in obesity with progressive

SUBMITTER: Lee J 

PROVIDER: S-EPMC12328564 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature