Mild hypothermia attenuates hepatic ischemia-reperfusion injury by regulating FoxO1/PPARα pathway.

ABSTRACT: Hepatic ischemia-reperfusion injury (IRI) is a common complication of hepatectomy and liver transplantation. As far as we know, mild hypothermia (MH) is an effective measure to alleviate liver IRI. However, the precise mechanisms have not been fully elucidated. This study investigated the regulatory role of FoxO1/PPARα-mediated energy metabolism in MH-alleviated IRI. Results showed a significant reduction in PPARα expression during liver IRI. Moreover, high PPARα level in post-IR liver specimens correlated with improved liver transplantation outcomes. MH increased blood glucose, elevated gluconeogenesis, and promoted fatty acid oxidation (FAO), indicating a high metabolic state, and also enhanced PPARα expression. Additionally, PPARα promoted FAO and gluconeogenesis, thereby enhancing MH's

SUBMITTER: Lu Z 

PROVIDER: S-EPMC12328581 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature