CREB5 promotes tumorigenicity and upregulates druggable cell surface modalities in basal-like breast cancer.

ABSTRACT: Basal-like breast cancers (BLBC) have limited targeted therapies and poor outcomes. We found that CREB5 is a transcription factor overexpressed in 15% of BLBCs and was upregulated in breast cancers that metastasize to the brain. In cell lines, CREB5 overexpression regulated cell phenotypes and transcriptional changes, including IL13RA2, a cell surface receptor that is currently druggable and represents a novel target in BLBC.

SUBMITTER: Makovec A 

PROVIDER: S-EPMC12328604 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature