In silico decrypting of the bystander effect in antibody-drug conjugates for breast cancer therapy.

ABSTRACT: Antibody-Drug Conjugates (ADCs) are a promising cancer treatment that deliver toxic drugs directly to cancer cells, reducing harm to healthy tissue. A key feature of newer ADCs is the "bystander effect," in which nearby cancer cells are also affected by passive diffusion. However, the mechanisms underlying this effect remain unclear. Using computer simulations, this study investigates how the drug's ionization state and the linker connecting it to the antibody influence its ability to cross cell membranes. The results show that the ionization state of the drug impacts its membrane permeability, as charged molecules encounter resistance when moving through the membrane's hydrophobic core. Moreover, the study reveals that the linker increases the drug's overall size and hydrophobicity, there

SUBMITTER: Cruz VL 

PROVIDER: S-EPMC12328607 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature