The acquisition of additional control over quorum sensing regulation reduces the variability of final cell density in Burkholderia.

ABSTRACT: Bacteria usually possess more than one quorum sensing (QS) regulatory modules that sometimes form complex regulatory networks. These configurations have evolved through the integration of novel transcription factors into the native regulatory systems. However, the selective advantages provided by these alternative configurations on QS-related phenotypes is poorly predictable only based on their underlying network structure. Here, we show that the acquisition of extra regulatory modules of QS has important consequences on the overall regulation of microbial growth by significantly reducing the variability in the final cell density in Burkholderia. By mapping the distribution of horizontally transferred QS modules in extant bacterial genomes, we found that these tend to add up to already-pre

SUBMITTER: Fondi M 

PROVIDER: S-EPMC12328628 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature