Neutrophil-to-Lymphocyte ratio as surrogate for JAK2^V617F suppression and event-free survival in polycythemia vera.

ABSTRACT: Chronic systemic inflammation is a key driver of polycythemia vera (PV) progression, but the immunomodulatory effects of current treatments remain poorly defined. The neutrophil-to-lymphocyte ratio (NLR) is an accessible biomarker of systemic inflammation proven in other contexts, but its role in monitoring PV disease activity has not been established. Using data from three of the largest PV clinical trials, we evaluated the effects of PV therapies on NLR and its relationship with molecular response and clinical outcomes. In 404 hematocrit-controlled patients from the ECLAP study, hydroxyurea (HU) failed to significantly lower NLR (p = 0.11) due to the parallel declines in ANC and ALC. Neither leukocyte counts nor NLR were significantly reduced by phlebotomy in ECLAP patients treated witho

SUBMITTER: Barbui T 

PROVIDER: S-EPMC12328675 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature