The examination of in vitro photosensitizing efficacy of aloe-emodin loaded liposome following photodynamic therapy on melanoma cell lines.

ABSTRACT: This study focused on investigating the enhanced photoactive properties of liposomal aloe-emodin for photodynamic treatment (PDT). Aloe-emodin (A-E) was encapsulated in liposomes by using the copper ion gradient method. This study aimed to highlight the function of naturally occurring photoactive plant-based derivatives in liposomal formulations as simple alternative photosensitizers (PS) for melanoma photodynamic therapy (PDT). Furthermore, we aimed to show that phototoxic chemicals loaded into liposomes are less cytotoxic than non-encapsulated molecules, which we used in our previous study. To assess the effectiveness of liposome aloe-emodin as a photosensitizer in PDT on melanoma cell lines, we performed cellular uptake by flow cytometry, MTT assay to measure the cytotoxicity of a natur

SUBMITTER: Nowak-Perlak M 

PROVIDER: S-EPMC12328719 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature