Optic neuritis as a link between autoimmunity and dementia risk.

ABSTRACT:

Background

Our limited understanding of dementia's complex pathogenesis confines treatment options primarily to symptom management rather than targeting underlying disease processes, underscoring the need for innovative treatment and preventive strategies. This study aimed to examine the relationship between optic neuritis (ON), an autoimmune inflammatory condition of the optic nerve, and the risk of developing dementia.

Methods

This nationwide, population-based cohort study was conducted in Korea, analyzing a cohort of 15,286 ON patients newly diagnosed between 2010 and 2017 who were age and sex matched against 76,430 controls without ON. Primary outcomes were incident cases of Alzheimer's disease, vascular dementia, or other types of dementia. Cox proportional hazards regr

SUBMITTER: Kim J 

PROVIDER: S-EPMC12328802 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature