Collagen gene signature in the tumor microenvironment predicts survival and guides prognosis in bladder cancer.

ABSTRACT:

Background

Collagen, within the tumor microenvironment (TME), assumes a crucial function in the development of cancer. However, the expression of collagen genes in bladder cancer (BCa) remains inadequately comprehended. The aim of this study is to examine the collagen genes expression in the BCa TME, and construct a nomogram to predict the overall survival for patients diagnosed with BCa.

Methods

The Cancer Genome Atlas (TCGA) database (N = 401) and the Gene Expression Omnibus (GEO) database (N = 165) were employed for training and validation cohorts. The correlation between the collagen genes assay and overall survival was investigated using Cox regression analysis. Model construction employed the least absolute shrinkage and selection operator (LASSO) Cox regression algori

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12328850 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature