The influence of hepatic arterial blood flow rate on holmium microsphere distribution: an MRI study in perfused porcine livers.

ABSTRACT:

Background

Transarterial radioembolisation (TARE) is a treatment for liver malignancies, involving the injection of radioactive microspheres in the hepatic artery (HA). Tumour-to-nontumour uptake varies among patients, possibly influenced by patient-specific blood flow profiles. To examine the impact of HA blood flow rate and high microsphere dosages on microsphere distribution in normal liver parenchyma, ex vivo magnetic resonance imaging (MRI)-guided machine perfusion experiments were conducted in porcine livers.

Materials and methods

Porcine livers were subjected to oxygenated normothermic machine perfusion at three HA flow rates (0.02, 0.15, and 0.22 mL/min/g liver tissue; n = 3 per condition). Five fractions of 250 mg nonradioactive ¹⁶⁵Ho-loaded microspheres

SUBMITTER: Snoeijink TJ 

PROVIDER: S-EPMC12328857 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature