MRI ensemble model of plaque and perivascular adipose tissue as PET-equivalent for identifying carotid atherosclerotic inflammation.

ABSTRACT:

Background

Severe cerebrovascular events are associated with carotid atherosclerotic plaque progression and rupture that is mediated by inflammation. ¹⁸F-fluorodeoxyglucose ([¹⁸F]FDG) PET is important for assessing the inflammation of carotid atherosclerotic plaque, but it suffers from the limitations of radiation exposure. Additionally, inflammation of perivascular adipose tissue (PVAT) has been found to promote atherosclerosis progression through paracrine signaling mechanisms. The study aimed to develop an ensemble model based on carotid plaque and PVAT MRI radiomics for identifying highly inflammatory plaques (HIPs).

Results

159 asymptomatic carotid atherosclerosis patients (137 males; 65 ± 8 years old) with 209 plaques (104 HIPs) were consecutively

SUBMITTER: Yu F 

PROVIDER: S-EPMC12328859 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature