Neoantigen load as a predictor of relapse in early-stage NSCLC: features that agonise and antagonise prognosis.

ABSTRACT:

Background

Neoantigen-specific immune responses may help prevent cancer recurrence. We evaluated whether neoantigen load and/or properties could predict survival in early-stage non-small cell lung cancer (NSCLC).

Methods

Whole-exome sequencing (WES) data from 89 resected early-stage NSCLC patients were used to identify non-synonymous single-nucleotide variants (nsSNV) and to predict major histocompatibility complex class I neoantigens. Neoantigen load, differential aggretopicity index (DAI), neoantigen frequency (number of neoantigens per nsSNV) and neoantigen promiscuity (ability to bind multiple human leucocyte antigen (HLA) alleles) were assessed for association with time to recurrence (TTR) and recurrence-free survival (RFS).

Results

Higher neoantigen load was ind

SUBMITTER: Ye L 

PROVIDER: S-EPMC12328875 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature