Switchable electrochemical pathways for the selective C(sp³)-Ge bond formation.

ABSTRACT: The development of efficient and general strategies for constructing alkyl germanes is crucial due to their significant roles in various areas that impact human quality of life. Herein, we report a robust electrochemically driven method for the construction of alkyl germanes, utilizing a variety of functionalized alkyl nitriles and commercially available chlorogermanes. The developed decyanative germylation approach allows for the efficient and modular preparation of a wide range of structurally diverse alkyl germanes under mild reaction conditions. Notably, primary, secondary, and tertiary alkyl nitriles are all compatible. Furthermore, a series of natural product and drug-derived substrates undergo smooth late-stage functionalization, yielding the corresponding complex alkyl germanes.

SUBMITTER: Chen H 

PROVIDER: S-EPMC12329035 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature