PCR-based detection of hereditary mutations in <i>SLC2A9</i>, <i>BTBD17</i>, and <i>NECAP1</i> among native Korean dog breeds.

ABSTRACT:

Importance

Understanding the susceptibility of native Korean dogs to genetic diseases is important for animal welfare and breeding. However, little is known regarding the segregation of genetic variations associated with genetic diseases among native Korean dog breeds, highlighting the need for further research in this area.

Objective

A genome-wide analysis was conducted using the available whole genome sequencing (WGS) results of DongGyeongi, Sapsaree, and Jindo dogs to evaluate the presence of disease-associated mutations and develop polymerase chain reaction (PCR)-based typing methods.

Methods

Using WGS data from 32 individuals of DongGyeongi, Sapsaree, and Jindo dogs, variant calling was used to identify variants associated with canine genetic diseases in Online M

SUBMITTER: Kang M 

PROVIDER: S-EPMC12329054 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature