Characterization and immunogenic evaluation of feline calicivirus epidemic strains.

ABSTRACT:

Importance

The feline calicivirus (FCV) is globally prevalent with regional specificity in its distribution, but the significant differences among strains limit the efficacy of vaccines. Therefore, understanding the prevalence and biological characteristics of FCV holds immense significance in facilitating the development of novel vaccines and targeted pharmaceuticals.

Objective

This study aimed to understand the epidemiological status of the FCV in the Shandong region and identify candidate strains for vaccine development.

Methods

In this study, 41 FCV strains were obtained from Shandong province in China. Phylogenetic analysis was conducted based on the VP1. The FCV023 strain was selected for pathogenicity and immunogenicity analysis.

Results

Forty-one FCV st

SUBMITTER: Xue X 

PROVIDER: S-EPMC12329055 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature