Brain Volume Reductions and Relationship With Depression and Cognitive Functioning in Suicide in Older Adults: A Cross-Sectional and Longitudinal Study Using Bayesian Multilevel Modeling.

ABSTRACT:

Background

In older adults, depression with cognitive impairment may be a harbinger of early dementia and a risk factor for suicidal behavior. However, the neuroanatomical correlates of these impairments are unknown, particularly when examined longitudinally.

Methods

Older adults (N = 153, mean [SD] age = 62.8 [7.7] years; 86/67 [56%/44%] female/male) with either a history of suicide attempts (n = 46), depression with no history of suicide attempts (n = 72), or no psychiatric history (n = 35) completed T1 structural magnetic resonance imaging scans. Of these participants, 51 had repeated scans (days between scans mean [SD] = 415 [252], range = 90-1091). Bayesian multilevel modeling with false discovery rate correction tested cross-sectional group

SUBMITTER: Brown VM 

PROVIDER: S-EPMC12329088 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature