Assessment of Choriocapillaris in Healthy and Diseased Eyes Using 3-Dimensional Topographic Maps Based on OCT Angiography.

ABSTRACT:

Purpose

To achieve clear in vivo imaging and systematic quantification of choriocapillaris (CC), enabling the exploration of age-related and disease-related changes of CC within a large sample size.

Design

Cross-sectional study.

Participants

A total of 1050 eyes from 727 individuals, comprising 633 healthy eyes, 277 eyes with age-related macular degeneration (AMD), and 140 eyes with high myopia.

Methods

The 3-dimensional (3D) topographic maps of CC were obtained by performing image enhancement, depth reconstruction, and 3D rendering on a single OCT angiography enface image. Based on this map, we targeted key quantitative parameters to analyze vessel thickness, vascular complexity, vascular distribution uniformity, and blood perfusion of CC. We statistically ana

SUBMITTER: Liu X 

PROVIDER: S-EPMC12329102 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature