Transcriptome analysis of chicken fibroblast following transforming growth factor β1-mediated activation.

ABSTRACT: Wooden Breast (WB) myopathy is one of the most challenging problems facing the broiler industry. Fibrosis characterized by extracellular matrix (ECM) proteins has been recorded as the prominent pathological feature within the pectoralis major muscles affected by WB. During the process of fibrosis, fibroblasts are the key players. Transforming growth factor-β1 (TGF-β1) serves as the principal cytokine inducing fibroblast to myofibroblast Transition (FMT). The mechanism of TGF-β in regulating fibroblast activation remains unclear despite growing evidence of its involvement. The objective of this study was to establish an in vitro chicken fibroblast activation model using TGF-β1 stimulation, and to explore the transcriptomic changes during this process. Results indicated that TGF-β1 upregulat

SUBMITTER: Hou T 

PROVIDER: S-EPMC12329111 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature