Self-assembled and intestine-targeting florfenicol nano-micelles effectively inhibit drug-resistant <i>Salmonella typhimurium,</i> eradicate biofilm, and maintain intestinal homeostasis.

ABSTRACT: Antimicrobial resistance (AMR) is a growing public health crisis that requires innovative solutions. Emerging multidrug resistant (MDR) Salmonella typhimurium has raised concern for its effect on pathogenic infection and mortality in humans caused by enteric diseases. To combat these MDR Salmonella typhimurium pathogens, highly effective and broad-spectrum antibiotics such as flufenicol (FFC) need to be evaluated for their potent antibacterial activity against Salmonella typhimurium. However, the low solubility and low oral bioavailability of flufenicol need to be addressed to better combat AMR. In this work, we develop a novel nano-formulation, flufenicol nano-micelles (FTPPM), which are based on d-α-tocopherol polyethylene glycol 1,000 succinate (TPGS)/poloxamer 188

SUBMITTER: Zuo R 

PROVIDER: S-EPMC12329119 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature