Extracellular vesicles as prospective biological indicators for midgestational placental complications in the mouse.

ABSTRACT:

Background

Placental dysfunction is often associated with reproductive complications such as preeclampsia, intrauterine growth restriction (IUGR), and preterm birth. Currently, the early diagnosis and intervention of these pathologies remain challenging due to the invasive nature of placental tissue sampling. Liquid biopsies of extracellular vesicles (EVs) released from the placenta have emerged as a prospective minimally invasive diagnostic strategy that could provide insight into the maternal-fetal interface because of the active role EVs play in mediating placental development and function. However, the lack of information on EVs directly from placenta at disease onset has questioned the representativeness of placental EVs as pathological indicators. To address these concerns, t

SUBMITTER: Lee E 

PROVIDER: S-EPMC12329223 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature