Absolute impact of lipid levels on coronary heart disease in a real-world primary prevention cohort of 730,236 people.

ABSTRACT:

Background and aims

The impact of the association of LDL-c levels with coronary heart disease is unambiguous in people with previous cardiovascular disease. In primary prevention, however, it has been poorly studied. We analyzed the impact of the association of lipid levels with coronary heart disease in a population with no previous cardiovascular disease. We included potential variations by sex and age.

Methods

Retrospective cohort analysis of records from the SIDIAP Catalan database, Spain. We selected ≥35-year-olds without previous cardiovascular disease or lipid-lowering medications. The LDL, HDL, and triglycerides levels were the exposure and coronary heart disease was the outcome. Cox regression and Lin additive models estimated the relative and absolute associations,

SUBMITTER: Alves-Cabratosa L 

PROVIDER: S-EPMC12329289 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature