A modular polymer platform for efficient mRNA delivery in cancer immunotherapy.

ABSTRACT: The use of mRNA for prophylactic and therapeutic applications, such as treating coronavirus and cancer, has garnered significant attention. However, owing to the inherent labile nature of mRNA, it requires robust delivery platforms to enable effective mRNA-based therapies. While lipid nanoparticles (LNPs) have shown success in mRNA delivery, they face challenges in terms of safety, storage and manufacturing costs. Polymeric mRNA delivery platforms have emerged as promising alternatives due to their structural versatility, durability, and transfection efficiency. This study presents PFHA-PEI-mRNA-HP, a polymeric mRNA delivery nanoplatform that utilizes simultaneous fluorination and heparinization of low molecular weight polyethylenimine (PEI)-based mRNA complexes to enhance performance. The

SUBMITTER: Lin G 

PROVIDER: S-EPMC12329489 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature