Cognitive impairment and p-tau217 are high in a vascular patient cohort.

ABSTRACT:

Introduction

Vascular comorbidities are modifiable contributors to cognitive impairment and Alzheimer's disease (AD), yet brain health outcomes are rarely evaluated in cardiovascular patients.

Methods

This study prospectively evaluated cognition and AD pathology in 162 community-dwelling adults with asymptomatic cardiovascular disease who did not have a clinical diagnosis of dementia or cognitive impairment.

Results

Twenty-nine percent of the cohort had Montreal Cognitive Assessment (MoCA) scores indicative of cognitive impairment or dementia after adjusting for age, sex, and education based on National Alzheimer's Coordinating Center normative data. AD blood biomarker phosphorylated tau217 was elevated in 55% of the cohort, significantly associated with decreased MoC

SUBMITTER: French SR 

PROVIDER: S-EPMC12329572 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature