Multi-Scale Analysis of Regional Pathology in the Human Trapezium During Osteoarthritis Progression.

ABSTRACT: Trapeziometacarpal (TMC) osteoarthritis (OA) is a prevalent condition that significantly impacts hand function and quality of life. In this study we sought to close gaps in knowledge related to the initiation and progression of TMC OA on the tissue scale by evaluating the morphology and gross appearance, wear patterns, mechanical properties, subchondral bone morphology, and histological characteristics of the tissue across a spectrum of disease severity and by correlating each of these properties to the clinically assessed radiographic grade. Thirty-two cadaveric hand specimens were first assigned a radiographic grade by three hand surgeons. Trapezia were then evaluated for cartilage wear and eburnation. Cartilage mechanics were assessed via indentation testing across the TMC surface. Bone

SUBMITTER: Stoeckl BD 

PROVIDER: S-EPMC12329623 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature