Sustained YAP1 signaling alters the fates of lutein and Mullerian mesenchymal cells in mice.

ABSTRACT:

In brief

The Hippo signaling pathway plays crucial roles in various processes related to development and tissue homeostasis. This study demonstrates that sustained YAP1 activity can influence cell fate within the reproductive system, specifically in lutein and Müllerian mesenchymal cells, causing them to transdifferentiate into myofibroblasts.

Abstract

Recent reports have suggested that the Hippo intracellular signaling pathway is required for homeostasis in a variety of tissues, including the ovary and female reproductive tract. To further define the role of the Hippo effector YAP1 in the female reproductive system, transgenic mouse models were designed to direct the expression of a dominant stable mutant form of YAP1, termed YAP5SA, to the granulosa cells of antral follicl

SUBMITTER: Berube M 

PROVIDER: S-EPMC12329688 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature