The Associations of Air Pollution Mixture Exposure with Plasma Proteins in an Elderly U.S. Panel.

ABSTRACT: The impact of air pollution exposure on circulating proteins remains underexplored, particularly in vulnerable elderly populations. This study investigated the individual and joint effects of air pollutants on circulating proteins in 208 elderly participants from the Cancer Prevention Study-II Nutrition Cohort. Prediagnostic plasma samples were collected (1998-2001), and 484 proteins were measured using the Olink platform. Annual average exposures to six air pollutants in the calendar year of blood draw were estimated. We used linear regression for individual pollutants and quantile g-computation for mixture effects, adjusting for confounders, considering multiple comparison correction, and testing interactions with smoking status. Pathway enrichment and protein-protein interaction analyse

SUBMITTER: Tang Z 

PROVIDER: S-EPMC12329713 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature