Association between prediagnostic serum metabolites and pancreatic ductal adenocarcinoma risk in two prospective cohorts.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is highly fatal, with incidence rising worldwide. Metabolomics may provide insight into etiology and mechanisms contributing to pancreatic carcinogenesis. We examined associations between 1483 prediagnostic (up to 24 years) serum metabolites and PDAC in nested case-control studies within a cohort of male Finnish smokers and another of American men and women (n = 732 matched pairs). We used conditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals per standard deviation increase in log-metabolite level within each cohort and combined using fixed-effect meta-analyses. We performed elastic net regression (EN) to select metabolites and calculated area under the curve (AUC) for established PDAC risk factors (smoking, diabe

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12329778 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature