Epidemiological insights and survival patterns in neuroendocrine neoplasia: a geographic perspective.

ABSTRACT: Neuroendocrine neoplasms, though rare, have shown marked increases in global incidence and prevalence over the past decade, as demonstrated by cancer registry data and studies from specialised tertiary centres. However, it remains unclear whether this represents a true increase in incidence or enhanced detection capabilities across various countries. This review aims to analyse and discuss recently published data on the worldwide epidemiology of gastroenteropancreatic NEN, and bronchopulmonary NEN and explore potential trends and differences in incidence rates between large and small nations according to demographics, primary sites, grade and stage. Following PRISMA guidelines, 59 cohort studies published between 2014 and 2024 were analysed. Findings reveal mixed demographic patterns, with

SUBMITTER: Mangion J 

PROVIDER: S-EPMC12329783 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature