Epicatechin inhibits inflammatory injury in preeclampsia extravillous trophoblasts.

ABSTRACT:

In brief

Preeclampsia is a severe pregnancy-related complication that can result in adverse maternal and fetal outcomes. Current therapeutic options for preeclampsia remain limited. This study demonstrates that epicatechin can inhibit pyroptosis in extravillous trophoblasts and block the activation of the NF-κB signaling pathway, thereby offering a novel therapeutic approach for the management of preeclampsia.

Abstract

Preeclampsia (PE) is characterized as new-onset hypertension and proteinuria after 20 weeks of gestation, and affects 5-7% pregnant women globally. PE is associated with a systemic inflammatory status that is overly activated and contributes to dysregulated extravillous trophoblasts (EVTs) invasion and impaired spiral vessel remodeling. Recent studies showed t

SUBMITTER: Li M 

PROVIDER: S-EPMC12329818 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature