Urinary pneumococcal serotype detection among children with and without community-acquired pneumonia.

ABSTRACT:

Background

Urinary antigen detection (UAD) assays can address diagnostic challenges with culture-based identification of S. pneumoniae. We aimed to evaluate the utility of Pfizer's UAD1 and UAD2 assays for pneumococcal serotype surveillance in children with community acquired pneumonia (CAP) or upper respiratory tract infections (URI).

Methods

From March 2021-December 2023, children 3 months to 5 years who presented to the Children's Hospital Colorado Emergency Department with respiratory symptoms were enrolled as CAP or URI; healthy children served as controls. Nasal swabs were tested for pneumococcus by PCR. UAD assays identified pneumococcal serotypes from urine. Groups were compared using descriptive statistics.

Results

We enrolled 407 controls, 202 with URI, and

SUBMITTER: Ambroggio L 

PROVIDER: S-EPMC12329884 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature