Clinical Risk Factor for Detected Distant Metastasis and Anaplastic Transformation After Reoperation in Recurrent/Persistent Differentiated Thyroid Cancer: A Retrospective Cohort Study.

ABSTRACT:

Objectives

Research on detected distant metastasis or anaplastic transformation in recurrent/persistent differentiated thyroid cancer is limited. We analyzed the clinical factors associated with detected distant metastasis or anaplastic transformation following reoperation for differentiated thyroid cancer.

Methods

This retrospective review included 336 patients who underwent reoperation for differentiated thyroid cancer with detection of distant metastasis or anaplastic transformation following reoperation. The hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated.

Results

Distant metastasis was detected in 45 patients (45/336, 13.4%) after reoperation. The risk of distant metastasis was higher for patients of male sex (adjusted HR: 2.373; 95% CI: 1.1

SUBMITTER: Kim MS 

PROVIDER: S-EPMC12329911 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature