Alterations in serum exosomal miR-1207-5p levels reflect severity and progression risk in type 2 diabetic kidney disease.

ABSTRACT:

Background

Diabetic kidney disease (DKD) is a frequent microvascular complication of diabetes and the predominant cause of end-stage renal disease worldwide. Dysregulated microRNA (miRNA) expression contributes to DKD pathogenesis. This study aimed to determine the clinical significance of serum exosomal miR-1207-5p expression in type-2 DKD.

Methods

Serum exosomes were isolated from 51 DKD patients stratified into low-, medium-, high-, and extremely high-risk groups and 11 control individuals. Exsosomal miR-1207-5p expression was determined by real-time-quantitative polymerase chain reaction (RT-qPCR), and its relationship with the patient's clinical records was explored. Bioinformatics analyses were performed to determine miR-1207-5p target genes using tools available onlin

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12329926 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature