Acetylsalicylic acid and vorapaxar are less active, while 4-methylcatechol is more active, in type 1 diabetic patients compared to healthy controls.

ABSTRACT:

Introduction

It is well known that platelets from diabetic patients can be resistant to clinically used antiplatelet drugs.

Methods

To assess the phenomenon in more detail, 50 adult patients suffering from type 1 diabetes mellitus (T1D) were recruited and their responses to 7 platelet aggregation inducers, as well as to 3 clinically used antiplatelet drugs (acetylsalicylic acid /ASA/, ticagrelor and vorapaxar) and one experimental compound, 4-methylcatechol, were assessed ex vivo. A control group of 50 generally healthy age-matched controls was also included for comparison.

Results

T1D patients exhibited a lower aggregation reaction to 3 inducers but were conversely more resistant to the effect of ASA and vorapaxar than controls. Ticagrelor tended to be less active in

SUBMITTER: Paclikova M 

PROVIDER: S-EPMC12329942 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature