Biological aging and incident cardiovascular diseases in individuals with diabetes: insights from a large prospective cohort study.

ABSTRACT:

Background

Biological aging is a critical risk factor of age-related diseases, but its impact on diabetic individuals remains unclear. This study aimed to examine the associations of biological aging with the incident cardiovascular diseases (CVDs) and life expectancy loss in diabetic individuals.

Methods

We included 12,828 diabetic individuals in UK biobank. Biological aging was calculated by Klemera-Doubal method Biological Age (KDMAge) and phenotypic age (PhenoAge). Cox proportional hazard models were fitted to investigate the associations of biological aging with incident coronary heart disease (CHD), atrial fibrillation (AF), heart failure (HF), stroke, and degenerative valvular heart disease (VHD) in diabetic individuals. We also evaluated life expectancy loss in accel

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC12329960 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature