Palmitate enhances MSC immunomodulation of human macrophages via the ceramide/CCL2 axis in vitro.

ABSTRACT:

Background

The immunomodulatory function of human mesenchymal stromal cells (MSCs) strongly depends on external factors; such as cytokines and other signalling molecules encountered in the disease microenvironment. An insufficiently inflammatory environment can fail to activate MSCs, and certain signals can impair their function. Obesity is on the rise worldwide, making it an additional factor to be considered prior to MSC therapy, as the microenvironment presents its own challenges. Elevated levels of serum free fatty acids, specifically palmitate, have the potential to affect MSC therapy. Palmitate-exposure has been shown to impair MSC immunomodulation of T cells in vitro. However, this is yet to be studied in the context of macrophages.

Methods

MSCs from three independent

SUBMITTER: Tunstead C 

PROVIDER: S-EPMC12329961 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature