Evaluation and study of adverse reactions to imiglucerase based on the FAERS database.

ABSTRACT:

Objective

This study aims to evaluate the adverse drug reactions associated with imiglucerase in the treatment of Gaucher disease by analyzing data from the FDA Adverse Event Reporting System (FAERS) database.

Methods

A comprehensive analysis was conducted on 166,800,135 adverse event reports from the FAERS database, covering the period from the first quarter of 2004 to the fourth quarter of 2023. The data were processed using R software and analyzed using multiple disproportionality methods, including Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-Item Gamma Poisson Shrinker (MGPS). These methodologies were applied to identify significant adverse reaction signals across various System Organ C

SUBMITTER: Hong P 

PROVIDER: S-EPMC12329963 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature