Effects of ultrasound-guided transversus abdominis plane block with combined dexmedetomidine and dexamethasone on the stress and immune function.

ABSTRACT:

Background

Ultrasound-guided transversus abdominis plane (TAP) block is widely used to provide effective postoperative analgesia and facilitate enhanced recovery after laparoscopic radical colectomy. However, the duration of TAP block is often limited by the pharmacokinetics of local anesthetics, and evidence regarding optimal adjuvant combinations to prolong its efficacy remains scarce.

Methods

In this prospective, randomized controlled trial, 160 patients undergoing elective laparoscopic colectomy were randomly assigned to four groups (n = 40 each): Control (ropivacaine alone), Dexmedetomidine group (ropivacaine + dexmedetomidine), Dexamethasone group (ropivacaine + dexamethasone), and Combination group (ropivacaine + dexmedetomidine + dexamethasone). Primary outcomes incl

SUBMITTER: Su C 

PROVIDER: S-EPMC12329993 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature