Blood cell perturbation responses mediate the causal relationship between the gut microbiota and asthma: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Asthma is a complex and heterogeneous disease presenting with a wide range of phenotypes. While prior studies have highlighted the importance of gut microbiota in asthma development, the extent of their influence varies. The exact causal links between gut microbiota and asthma remain to be fully understood, and the role of blood cell perturbation responses as potential mediators in this relationship remains unclear.

Methods

To elucidate the connections between gut microbiota, blood cell perturbation responses, and asthma, we utilized data from comprehensive genome-wide association studies (GWAS). Our investigation covered six distinct asthma phenotypes: unspecified asthma, eosinophilic asthma, allergic asthma, childhood asthma, non-allergic asthma, and obesity-rel

SUBMITTER: Bi J 

PROVIDER: S-EPMC12329996 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature