Early preterm antenatal corticosteroids and neonatal outcomes for twin pregnancies: a propensity score-weighted cohort study.

ABSTRACT:

Background

Administering antenatal corticosteroids (ACS) to those at risk for early-preterm delivery has been widely recommended, yet the evidence regarding twin pregnancies remains insufficient and controversial.

Methods

This 8-year retrospective cohort study analyzed twin pregnancies at risk for early preterm birth (24 + 0 to 33 + 6 weeks of gestation) in a university-affiliated hospital in China from 2013 to 2020. Propensity score overlap weighting was used to analyze the association between ACS administration and the risk of neonatal outcomes. The primary outcome was the composite neonatal respiratory morbidity, defined as at least one of the following: postnatal occurrences respiratory distress syndrome, mechanical ventilation, surfactant administration, transferred wit

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12330002 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature