Sulfoquinovose is exclusively metabolized by the gut microbiota and degraded differently in mice and humans.

ABSTRACT:

Background

Sulfoquinovose (SQ) is a green-diet-derived sulfonated glucose and a selective substrate for a limited number of human gut bacteria. Complete anaerobic SQ degradation via interspecies metabolite transfer to sulfonate-respiring bacteria produces hydrogen sulfide, which has dose- and context-dependent health effects. Here, we studied potential SQ degradation by the mammalian host and the impact of SQ supplementation on human and murine gut microbiota diversity and metabolism.

Results

¹³CO₂ breath tests with germ-free C57BL/6 mice gavaged with ¹³C-SQ were negative. Also, SQ was not degraded by human intestinal cells in vitro, indicating that SQ is not directly metabolized by mice and humans. Addition of increasing SQ concentrations to

SUBMITTER: Krasenbrink J 

PROVIDER: S-EPMC12330013 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature