Chest CT-based analysis of radiomic and volumetric differences in epicardial adipose tissue in HFrEF patients with and without AF.

ABSTRACT:

Aims

Epicardial adipose tissue (EAT) has been implicated in atrial fibrillation (AF). While increased EAT volume (EATV) and EATV index (EATVI) are associated with AF, decreased values have been observed in heart failure with reduced ejection fraction (HFrEF). However, radiomic and volumetric differences of EAT in HFrEF patients with AF (HFrEF-AF) and without AF (HFrEF) remain unexplored.

Methods

This case-control study enrolled 120 patients (60 HFrEF and 60 HFrEF-AF). EATV and EATVI were quantified from non-contrast chest CT scans. Radiomic features were extracted using PyRadiomics, and reproducibility was assessed using intraclass correlation coefficients (ICCs). Feature selection was performed using the Boruta algorithm embedded in a five-fold cross-validation framework. U

SUBMITTER: Song XY 

PROVIDER: S-EPMC12330031 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature