Efficacy and safety of mineralocorticoid receptor antagonists in kidney transplant patients: an updated meta-analysis of randomized controlled trials.

ABSTRACT:

Background

In patients with chronic kidney disease, mineralocorticoid receptor antagonists (MRAs) exert a reno-protective effect through its anti-inflammatory and antifibrotic effects. Less is known about the efficacy of MRAs in kidney transplant (KT) recipients. This meta-analysis aims to systematically assess the efficacy of MRAs in KT recipients.

Methods

PubMed, Embase and Cochrane databases were searched for randomized controlled trials (RCTs) that compared MRAs to placebo in KT recipients and reported the outcomes of (1) glomerular filtration rate (GFR); (2) serum creatinine; (3) systolic (SBP) and diastolic blood pressure (DBP); (4) hyperkalemia; and (5) interstitial fibrosis and tubular atrophy (IFTA) scores. Heterogeneity was examined with I2 statistics. A random-eff

SUBMITTER: Dibo P 

PROVIDER: S-EPMC12330037 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature