MiR-107 modulates EMT progression of OSCC by targeting SNCG and inhibiting the ERK/NF-κB signaling pathways.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) is marked by aggressive metastasis and poor prognosis, with epithelial-mesenchymal transition (EMT) serving as a pivotal process in tumor metastasis. Consequently, identifying critical targets and elucidating the underlying mechanisms that drive OSCC metastasis are vital for enhancing patient prognosis. This study sought to clarify the significance and underlying molecular mechanisms of the miR-107/synuclein gamma (SNCG) axis in the regulation of OSCC migration, invasion, and EMT progression.

Methods

Peripheral blood from 26 OSCC patients and 24 controls assessed miR-107 expression, with GEO analysis for clinical significance. The effects of miR-107 and SNCG on OSCC migration, invasion and EMT in vivo and in vitro were assessed

SUBMITTER: Liu H 

PROVIDER: S-EPMC12330075 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature