Menopausal status, transition, and age at menopause with accelerated biological aging across multiple organ systems: findings from two cohort studies.

ABSTRACT:

Background

Biological aging is a heterogeneous process that varies across organs and systems. The dynamic hormonal changes during the menopausal transition may have profound and organ-specific impacts on biological aging. However, the relationship between the menopausal transition and both comprehensive and organ-specific biological aging remains poorly understood. This study aimed to investigate the associations between menopausal factors and both comprehensive and organ-specific biological aging, as well as the modifying role of reproductive history.

Methods

This study included 37,244 women from the China Multi-Ethnic Cohort (CMEC) and 140,479 from the UK Biobank (UKB). Menopausal factors included menopausal status, menopausal transition, and age at menopause. Comprehensiv

SUBMITTER: Xiang Y 

PROVIDER: S-EPMC12330081 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature