Calcium overload via PVT1 reprograms neutrophil fate and constrains gastric cancer progression.

ABSTRACT:

Background

The aberrant upregulation of PVT1 in gastric cancer (GC) has emerged as a critical molecular marker, while its mechanism of remodeling the tumor microenvironment (TME) through metabolic regulation remains unclear. This study aims to unveil the novel mechanism by which PVT1 regulates the fate determination of tumor-associated neutrophils (TANs) via the calcium signaling pathway.

Methods

Clinical analysis of 90 GC cases revealed a correlation between PVT1 expression and neutrophil infiltration in tumor tissues. Mechanistically, multi-omics integration of transcriptomics and 4D-label-free quantitative proteomics identified PVT1-associated pathways driving GC progression. Functional validation through in vitro and in vivo models demonstrated PVT1's oncogenic role, whi

SUBMITTER: Wang D 

PROVIDER: S-EPMC12330090 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature