Metabolic landscape uncovers remodeling of T cell immunity affected by fatty acid desaturase in Parkinson's disease at single-cell resolution.

ABSTRACT:

Background

Peripheral activated T cells cross the blood-brain barrier, partake in neuroinflammation, and induce dopaminergic neuron degeneration through characteristics such as cell adhesion and immune response in Parkinson's disease (PD). Metabolic activity, which can regulate and be regulated by cellular signaling pathways, has a profound impact on the differentiation and function of T cells. However, a characterization of T-cell metabolic heterogeneity at single-cell resolution in PD is still lacking. Here, combining metabolic gene expression profiling and pathway activity algorithm, we studied the metabolic programs in PD-associated T cells.

Results

Cytotoxic T cells (CTLs) with adhesive properties dominated the proportion in PD patients based on the distribution of T ce

SUBMITTER: Yan S 

PROVIDER: S-EPMC12330092 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature