Investigating the shared genetic information between serum concentration levels of liver enzymes and cholelithiasis.

ABSTRACT:

Background

Liver injury is associated with cholelithiasis, with changes in liver enzyme levels potentially influencing cholelithiasis risk. This study investigates the shared genetic basis between serum levels of four liver enzymes and cholelithiasis using summary data from large-scale genome-wide association studies (GWAS).

Methods

We assessed genetic correlation between liver enzymes and cholelithiasis, and performed local genetic correlation analysis to identify shared genomic regions. A cross-trait meta-analysis identified significant SNPs (single nucleotide polymorphisms) shared between the enzymes and cholelithiasis. To explore causal effects, we applied both two-sample Mendelian randomization and multivariable Mendelian randomization. Heritability-based enrichment ana

SUBMITTER: Tian W 

PROVIDER: S-EPMC12330097 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature