Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China.

ABSTRACT:

Background

Immunocompromised cancer patients represent a susceptible population for enterococcal infections. While linezolid remains the primary therapeutic option for vancomycin-resistant Enterococcus (VRE) infections, the emergence of linezolid-resistant Enterococcus (LRE) worldwide has not only exacerbated public health risks but also posed significant challenges to clinical treatment. This study aimed to analyze the prevalence of LRE isolates among cancer patients in China and to investigate the mechanisms of linezolid resistance.

Methods

A total of 656 non-repetitive Enterococcus isolates were collected. The susceptibility of Enterococcus to linezolid was determined using the broth microdilution method, and the mechanisms of linezolid resistance were explored through wh

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12330145 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature